VitaminDdeficiency is frequent among patients with heart failure (HF) and diabetes, disorders associated with exercise intolerance\nand muscle weakness. This study aims to search for associations between vitamin D sufficiency and physical function indexes in\npatients with HF and diabetes. A cross-sectional study of 146 HF patients, 39.7% with diabetes, at a Brazilian tertiary outpatient\nclinic was performed. Patients underwent clinical evaluation, 6-minute walk test (6MWT), handgrip strength, physical activity\nlevel (IPAQ), and biochemical evaluations including serum 25-hydroxyvitamin D. Classification was done according to vitamin D\nstatus (?30 ng/dL, sufficient) and presence/absence of diabetes in vitamin sufficient, no diabetes (DS-C, n = 25), vitamin sufficient,\ndiabetes (DS-DM, n = 18), vitamin deficient, no diabetes (DD-C, n = 63), and vitamin deficient, diabetes (DD-DM, n = 40).\nPatients age was 55.4 �± 8 yrs; 70.5% had vitamin D deficiency. Clinical characteristics were similar among groups. Total time\nexpended in physical activity was similar among groups (P = 0.26). DS-C covered higher distances in the 6MWT (392 �± 60\nm) versus DD-DM (309 �± 116 m); P = 0.024. Handgrip strength was similar among groups but tended to lower levels in DD-DM\n(P = 0.074) even after being adjusted to physical activity (P = 0.069). Vitamin D deficiency can influence physical function in HF\ndiabetic patients.
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